Pore-forming agents have a significant influence on the pore structure of hydrogels. In this\nstudy, a porogenic technique was employed to investigate the preparation of macroporous hydrogels\nwhich were synthesized by radical copolymerization of carboxymethyl xylan with acrylamide and\nN-isopropylacrylamide under the function of a cross-linking agent. Six kinds of pore-forming agents\nwere used: polyvinylpyrrolidone K30, polyethylene glycol 2000, carbamide, NaCl, CaCO3, and\nNaHCO3. The application of these hydrogels is also discussed. The results show that pore-forming\nagents had an important impact on the pore structure of the hydrogels and consequently affected\nproperties of the hydrogels such as swelling ratio and mechanical strength, while little effect was\nnoted on the thermal property of the hydrogels. 5-Fluorouracil was used as a model drug to study the\ndrug release of the as-prepared hydrogels, and it was found that the drug release was substantially\nimproved after using the NaHCO3 pore-forming agent: a cumulative release rate of up to 71.05%\nwas achieved.
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